Evidence Passport
Precision psychiatry in schizophrenia: a meta-analysis of radiomics-based advanced neuroimaging
Top story 6 in the issue of 22 October 2026, in 33 AI Neuroscience.
Original source
Precision psychiatry in schizophrenia: a meta-analysis of radiomics-based advanced neuroimaging
Pooling 14 studies, diagnostic AUC was 0.81 (95% CI 0.73–0.88) with high heterogeneity; treatment-response AUCs were 0.80–0.88.
Evidence
Evidence: Peer-reviewed (evidence step 5 of 6)
Published after review by independent experts.
The story in three lines
- Key finding
- Across 14 studies, imaging radiomics models identified schizophrenia with a pooled AUC of 0.81 (I² 84.2%).
- Significance
- Clinical: brings together scattered small studies into one estimate for imaging biomarkers in psychosis.
- Takeaway
- Promising but uneven; high heterogeneity means it is not ready for diagnosis in clinic.
Study details (as stated by the source)
- Study design
- Systematic review and meta-analysis (PROSPERO CRD420261286782)
- Sample size
- 14 studies (8 in the diagnostic pooled analysis)
- Outcomes
- Diagnostic and treatment-response AUC
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